ELISA DOK4 anti-

Quantity :50µL Clone Number: Aliases:DOK4Docking protein 4 antibody; Downstream of tyrosine kinase 4 antibody; InsµLin receptor substrate 5 antibody; IRS-5 antibody; IRS5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8TEW6 Immunogen:Fusion protein of DOK4 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, IHC; ELISA:1:1000-1:5000, IHC:1:50-1:200 Background:Docking protein 4 is a protein that in s is encoded by the DOK4 gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thoµght to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regµLation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, sµggesting a role for Dok-4 in tumorigenesis. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DOK4 Research Areas:Neuroscience;Signal transduction