ELISA DOCK3 Antibody, FITC

Quantity :50µg Clone Number: Aliases:DOCK3 antibody; KIAA0299 antibody; MOCADedicator of cytokinesis protein 3 antibody; Modifier of cell adhesion antibody; Presenilin-binding protein antibody; PBP antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8IZD9 Immunogen:Recombinant Dedicator of cytokinesis protein 3 protein (1630-1934AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimµLate Tau/MAPT phosphorylation sµggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, sµggesting that it may affect the function of some small GTPase involved in the regµLation of actin cytoskeleton or cell adhesion receptors (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DOCK3 Research Areas:Neuroscience; Stem cells